FORMULATION AND EVALUATION OF SINTERED GASTRORETENTIVE TABLETS OF VILDAGLIPTIN USING DESIGN OF EXPERIMENT

Objective: The purpose of the study was to formulate and evaluate sintered gastro retentive tablets Vildagliptin using design experiments. Methods: Direct compression is process by which are compressed from powder mixture API suitable excipients done an automatic punching machine 6 mm punch. Prepared were kept in hot air oven at three different temperatures 50°C, 60°C, 70°C for periods 1, 2, 3 h. Results Discussion: physiochemical evaluation results blend all trails pass flow properties uniform density (i.e., Angle repose, Bulk density, Compressibility index, Hausner’s ratio). Among Formulations, Formulation F7 showed better such as repose F7(29.9), Hausners ratio F7(1.18), compressibility index (15.6) indicate good properties. prepared evaluated post thickness, hardness, Weight variation, friability, drug content found within limits. Each formulation analyzed spectrophotometric ally, each >80%. consisting polymers (stearic acid, carnauba wax) gum (xanthan gum) percentage release 95.8 12 developed formulations optimized Box Behnken achieve desired Conclusion: has solubility acidic pH. It absorption environment. By preparing floating Vildagliptin, its bioavailability can be enhanced more amount will absorbed stomach. having high melting point 158–160°C best thermal sintering technique. aim present Sintered Gastro Design Expert successfully achieved.